Drug balloon catheter spraying machine, a kind of ultrasonic spraying equipment specially used for drug coating of drug balloon catheter. It is equipped with micro-type ultrasonic nozzle or gathering ultrasonic nozzle, and the drug coating of the balloon catheter is prepared by ultrasonic spraying technology. It is characterized by accurate control of the dosage, uniform spraying coating, no pinhole orange peel and other defects. Equipped with special balloon catheter fixture and rotation mechanism, it can be used for drug coating of coronary balloon, peripheral balloon and other drug balloon catheters. It is a widely used precision drug balloon coating equipment at present.